Collegium Wikia
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Rapamycin is most importantly a geroprotectant.[1] It is an antibiotic that was extracted form the ground. Rapamycin is a natural antifungal antibiotic, a cytostatic agent: and an immunosuppressant, which functions in humans and is especially useful in preventing the rejection of kidney transplants. Rapamycin has been linked in studies on different organisms, from worms to humans, as a geroprotective substance.

Also known as Sirolimus. A macrolide compound that is used to coat coronary stents, and to treat a rare lung disease called lymphangioleiomyomatosis.

mTOR is the target of rapamycine. rapamycine is the best known mTOR inhibitor. [ Xie 16 ] mTOR forms two different protein complexes, mTORC1 and mTORC2; the former is acutely sensitive to rapamycin whereas the latter is only chronically sensitive to rapamycin in vivo. [ Apelo 16 ]

Recently rapamycin has shown effective in the inhibition of growth of several human cancers and murine cell lines.[5] Rapamycin is the main mTOR inhibitor, but deforolimus (AP23573), everolimus (RAD001), and temsirolimus (CCI-779), are the newly developed rapamycin analogs.In this study, the researchers applied deep-learned neural networks to profile the safety and gene- and pathway-level similarity of more than 800 natural compounds to metformin and rapamycin, in an effort to identify natural compounds that can mimic the effects of these anti-cancer and anti-aging drugs while remaining free of the adverse effects associated with them. [ eurekalert.org 17 ]

Referred to in 17 as "Novel hybrid" inhibitors of mTOR (mammalian target of rapamycin kinase) that selectively target mTORC1 (mammalian target of rapamycin complex 1) and completely inhibit downstream phosphorylation of its substrates for cancer treatment as well as regenerative medicine, aging (see new publication added for these two indications) and autism (TSC mutations).

Its analogs are referred to as ‘rapalogs’.

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  • Bio-Origin: macrolide produced by the bacterium Streptomyces hygroscopicus. [ Apelo 16 ]
  • Functions: Antitumor, Anticancer, Antiaging, Antifungal, Antibacterial
  • Mimetics of rapamycin: epigallocatechin gallate and isoliquiritigenin as strong mimetics of rapamycin
  • Side-effects: diet might make the difference between those who develop diabetes while on rapamycin and those who do not. [ Puigserver 12 ]
  • History: Isolated from a soil example at Easter Island, called "a new antifungal antibiotic" and named rapamycin in 1975 by Vézina it was found to inhibit Candida albicans.
  • See also: RapaLink-1 represents a new class of mTOR inhibitors that can overcome resistance to the first two generations of mTOR inhibitors. [ Flemming 16 ]
  • AQ-905= LIMBIC DRIFT, DREAMS, TRANCE-STATES AND FOETAL SENTIENCE. RAPAMYCIN IS MOST IMPORTANTLY A GEROPROTECTANT. WE MUST BECOME THE PITILESS CENSORS OF OURSELVES
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